Coronavirus UK: 12 different strains in March, one unique
At least a dozen different strains of coronavirus were spreading through the UK in March, a Government-funded study has found.
Leading genetic scientists analysed the genomes of the killer virus in 260 infected patients from all corners of the UK.
They say they have identified 12 unique lines of the virus, one of which has only ever been found in Britain – meaning it mutated on UK soil.
But the COVID-19 Genomics UK Consortium (COG-UK) said the number of strains ‘is very likely substantially higher’ due to under-sampling in the UK.
The scientists say most of the strains were imported from Italy and Spain, the worst-hit countries in the world at the time the research was carried out.
There is no suggestion that any of the strains are any more potent or infectious than another, infectious disease experts say.
Professor Paul Hunter, at the University of East Anglia, told MailOnline it is ‘entirely plausible’ this could happen to one of the strains if it continues to evolve.
The report, made public today, was given to the Government’s Scientific Advisory Group for Emergencies (Sage) in March to help them map the outbreak’s spread.
Other secret documents of scientific evidence that helped shape the Government’s response to the crisis were released today. They revealed:
- Ministers were warned lifting the coronavirus lockdown and then reimposing restrictions later would be seen by the public as a ‘serious failure of policy’;
- A traffic light system could be used to explain to the public the new rules when lockdown is eased, according to behavioural experts;
- Scientists urged the government to tell people to stop shaking hands the same day Boris Johnson was boasting about shaking hands with ‘everybody’;
- Officials were told employers could shun workers who have not had COVID-19 after lockdown, prompting people to actively try to catch the disease.

There are at least a dozen different strains of coronavirus ravaging the UK. The most common is the B.12.1 strain (pink) and the B.11 strain (green). The researchers did not make clear which strains were imported from other countries, nor did it disclose which one is unique to Britain

There is no suggestion that any of the strains are more potent or infectious than another, experts say. Pictured: Illustration of the novel coronavirus by the Center for Disease Control and Prevention (CDC)
The researchers did not make clear which strains were imported from other countries, nor did it disclose which one is unique to Britain.
All viruses mutate slightly as they spread through populations, which leads to small changes in their genetic material.
Scientists say the virus does this to overcome immune system resistance in different communities.
As part of the study, COG-UK researchers analysed patients in Belfast, Birmingham, Cambridge, Cardiff, Edinburgh, Exeter, Glasgow, Liverpool, London, Norwich, Nottingham, Oxford and Sheffield.
They found 12 unique strains, most of which had been imported from Europe. The report did not specify which countries, but said the majority of cases came from Italy. It found that strains had also come from China, the US and Australia.
Professor Hunter told MailOnline: ‘There are a number of issues with these strains – are they likely to cause different severity of disease? Are they likely to be more infectious? And are they capable of invalidating vaccines?
‘The answer to all three of these is that we have no idea. There is no suggestion from this study – or any other that I have read – that show these strains are more virulent or infectious that one another.
‘But it is plausible that one strain could mutate to the point where people with antibodies to an older strain are no longer immune to it.
‘These are called escape mutants, because they escape from the control of immunity.
‘It happens with influenza a lot. The current coronavirus does not seem to do this as fast, though, but it is plausible down the line.’
Professor Hunter said the main value of the report was that it helps scientists track the spread of the infection around the UK.
He said this would become crucial when easing out of lockdown.
Professor Hunter added: ‘This enables researchers to continue to track where it’s going and help enforce new rules to stop another outbreak.
‘Say you have a cluster in the north west of England, which is unexpected, and it is the same strain found predominantly in London, then you could see that is must’ve been spread by someone travelling from the capital.
‘You could use this to tell if someone had broken lockdown rules by travelling there, or you could close down a possible transmission passage [a train line, for example].’

Britain now has Europe’s highest coronavirus death toll: Official figures show 32,000 people in the UK had died from the infection by April 24 – and true count could now be closer to 45,000

Sir patrick Vallance told MPs: ‘But a lot of the cases in the UK didn’t come from China and didn’t come from the places you might have expected’

People returning from other hotspots such as China and a cruise ship off Japan, were put into camps for 14 days at the end of February, including one at Arrowe Park in Wirral (pictured on February 22)
The COG-UK is an innovative partnership of NHS organisations, the four Public Health Agencies of the UK, the Wellcome Sanger Institute and more than 12 academic institutions, including Cambridge University.
It is supported by £20million funding from the UK Department of Health and Social Care (DHSC), UK Research and Innovation (UKRI) and the Wellcome Trust.
It comes as damning new figures revealed today that Britain quarantined just 273 out of 18.1million people who arrived in the UK in the three months before the coronavirus lockdown.
The occupants of three flights from the outbreak ground zero in the Chinese city of Wuhan and another bringing home passengers from a cruise ship of Japan were the only ones taken to secure facilities in the UK.
But millions more entering the UK between the start of 2020 and March 22 were able to enter freely and only advised to self-isolate, according to figures obtained by the Guardian.
It came as it also emerged the UK suffered a ‘big influx’ of coronavirus from arrivals from Italy and Spain who were not quarantined.
Mapping of the Covid-19 genome shows that UK cases come from all over the world, chief scientific adviser Sir Patrick Vallance told MPs.
But a large number of cases in early March were from Europe and ‘seeded right the way across the country’ because Brits arriving back in the UK were allowed to return home.
Giving evidence to the Health and Social Care Committee this morning, Sir Patrick said that experts on the Scientific Advisory Group for Emergencies (Sage) had advised ministers they would have to be ‘extremely draconian’ in blocking travel from whole countries otherwise ‘it really was not worth trying to do it.’
‘Whether that was people returning from half-term, whether it is business travellers or not, we don’t know,’ he told MPs.
‘But a lot of the cases in the UK didn’t come from China and didn’t come from the places you might have expected.
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‘They actually came from European imports and the high level of travel into the UK around that time.’
At the weekend a senior minister finally confirmed visitors to the UK could face time in quarantine as the Government ‘actively’ considers stronger anti-coronavirus measures at the borders.
Transport Secretary Grant Shapps said that new arrivals could also be forced to download a new contract app onto their smartphone as a condition of entry.
New restrictions would make the UK one of the last countries to introduce them, with the country very much an outlier in recent weeks by not halting inbound flights or insisting arrivals are checked.
People arriving are currently advised to self-isolate but there is no enforced testing.
Home Secretary Priti Patel is believed to be among those who have demanded tougher rules for foreign visitors and the remaining Brits still abroad who make it home.
But Sir Patrick suggested stopping travel was of limited use unless action was taken against a wide-range of countries.
‘What was very clear, and I think you can see this now in retrospect, is that the idea that you can control this by stopping travel from one place doesn’t work unless it is of course the only source of import,’ he said this morning.
‘We have now in the UK sequenced 13,6000 viral genomes, we got imports from all over the place.
‘So quite early on the advice Sage gave was ”if you are going to do something on travel you either need to be extremely draconian – stop all travel from all sorts of countries – or it is really not worth trying to do it, trying to stop from one place because you won’t make it happen”.
‘So I think the answer is not, unless the country chose to do that, stopping travel anywhere and to … make sure that as people come back you have appropriate systems to isolate and make sure they are following the same rules as the rest of the country.’
Deputy chief medical officer Dr Jenny Harries, who was also giving evidence, added: ‘There are pros and cons which are not necessarily always obvious I think, between managing influx and outflux of passengers but also goods.
‘If you shut travel routes in, you are also shutting routes for various products which may be essential, not just for our population but all around the world.
‘At the moment most people who are coming back are coming back into the UK back home and they will immediately fall under social distancing regulations anyway.’