The study pioneer Nuri Firat Ince, associate professor of biomedical engineering, University of Houston earlier had contributed to a
(SOZ – the brain region that causes seizures) in the brain.
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This was done by detecting high-frequency oscillations (HFO) that form repetitive waveform patterns. This helps in further identifying their location in the SOZ.
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Epileptic Seizures and Technology
The work thereby lays the translational background for the upcoming study as the team plans to use those HFOs to close the loop, translating them into seizure control applications, a method never before explored. For this, the HFOs generated by the seizure onset zone must be able to be detected with an implantable system.
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“If this can be achieved, then HFOs can be strategically translated as a neurobiomarker into closed-loop seizure control applications. We hypothesize that pathologic stereotyped HFOs can be captured with the implantable Brain Interchange (BIC) system and spatial topography of these events can be utilized by the implantable system to deliver targeted electrical stimulation to achieve seizure control. If the outcomes of our research in acute settings become successful, we will execute a clinical trial and run our methods with the implanted BIC system in a chronic ambulatory setting,” says, Ince.
Source: Medindia
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