by Jordi Merino of Massachusetts General Hospital, US, and colleagues.
Both genetic and lifestyle factors are known to contribute to individual susceptibility to type 2 diabetes.
Previous studies have shown that adherence to a healthy lifestyle is associated with reduced risk of type 2 diabetes across genetic profiles, but whether genetic profiles, in part, interact with lifestyle factors was unclear.
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Low Diet Quality May Up Diabetes Risk
In the new study, researchers analyzed data from three extensive cohort studies, including 35,759 U.S. health professionals followed for 902,386 person-years of follow-up. The team found that, irrespective of genetic risk, a low diet quality, as compared to high diet quality, was associated with a 30% increased risk of type 2 diabetes (Pinteraction=0.69).
The relative risk of type 2 diabetes was 1.29 (95% CI 1.25-1.32, P0.001) per standard deviation increase in the global polygenic score𤤖ne measure of genetic risk㻡nd was 1.13 (1.09-1.17, P0.001) per 10-unit decrease in Alternate Healthy Eating Index, a measure of diet quality.
The joint association of low diet quality and increased genetic risk was similar to the sum of the risk for each factor alone (Pinteraction =0.30), further supporting independent associations.
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That said, one limitation of the study was that the cohort sampling might not necessarily generalize to other populations.
Merino adds, 孏his study provided evidence that the risk of type 2 diabetes attributed to increased genetic risk and low diet quality is similar to the sum of the risks associated with each factor alone. Such knowledge could serve to inform and design future strategies to advance the prevention of diabetes.�
Source: Eurekalert
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