Scientists have focused on identifying why few patients progress at slower rates and whether they might harbor proteins that protect the kidneys from the effects of diabetes.
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So, the study followed two groups of patients with type 1 or type 2 diabetes and varying degrees of diabetic kidney disease (358 total) for between 7 to 15 years.
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Patients who progressed slowly had higher amounts of the proteins ANGPT1, TNFSF12, and FGF20. The team confirmed this protective link in an independent group of 294 type 1 diabetics; they also found that FGF20 was elevated in healthy, non-diabetic parents of type 1 diabetics who remained free of kidney complications.
If validated in larger studies, this finding “could have a profound implication in future research on determinants of progressive renal decline in ,” the authors say. More studies are necessary to confirm a causal link between the 3 proteins and protection from diabetic kidney disease.
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Source: Medindia
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